Table 4.

In Vitro Activity of Omadacycline and Comparators Against Anaerobes

	Omadacycline			Tigecycline
Bacteria (No. of Isolates)	MIC50 (μg/mL)	MIC90 (μg/mL)	MIC Range (μg/mL)	MIC50 (μg/mL)	MIC90 (μg/mL)	MIC Range (μg/mL)
Bacteroides fragilis (21)	0.5	4	0.25 to 16	0.5	2	0.5 to 8
Bacteroides thetaiotaomicron (21)	1	4	0.12 to 16	1	8	0.25 to 16
Bacteroides vulgatus (21)	0.12	1	0.06 to 2	0.25	1	0.12 to 2
Bacteroides ovatus (15)	0.5	8	0.06 to 16	0.5	8	0.03 to 16
Clostridioides difficile (21)	0.25	0.5	0.25 to 8	0.25	0.25	0.25 to 4
Clostridium perfringens (22)	4	16	0.12 to 16	8	>16	0.25 to 16
Peptostreptococcus spp.a (22)	0.12	1	0.06 to 2	0.12	2	0.06 to 4

Adapted from Villano et al [17] and Stapert et al [24].

Abbreviation: MIC, minimum inhibitory concentration.

^aIncludes Peptostreptococcus micros (n = 11) and Peptostreptococcus anaerobius (n = 11).