Table 3.
Clinical Response by Infection Type and Size
| Parameter | Omadacycline (n = 676) | Linezolid (n = 671) | Difference (95% CI) |
|---|---|---|---|
| Wound infection | 312 | 318 | |
| ECR | 278 (89.1) | 269 (84.6) | 4.5 (–0.8 to 9.9) |
| IACR-PTE | 256 (82.1) | 248 (78.0) | 4.1 (–2.2 to 10.3) |
| Cellulitis/erysipelas | 209 | 202 | |
| ECR | 165 (78.9) | 164 (81.2) | –2.2 (–10.0 to 5.5) |
| IACR-PTE | 188 (90.0) | 178 (88.1) | 1.8 (–4.3 to 8.1) |
| Major abscess | 155 | 151 | |
| ECR | 140 (90.3) | 130 (86.1) | 4.2 (–3.1 to 11.8) |
| IACR-PTE | 131 (84.5) | 125 (82.8) | 1.7 (–6.6 to 10.2) |
| Lesion area ≤300 cm2 | 322 | 332 | |
| ECR | 286 (88.8) | 276 (83.1) | 5.7 (0.4 to 11.1) |
| IACR-PTE | 290 (90.1) | 271 (81.6) | 8.4 (3.1 to 13.8) |
| Lesion area >300–600 cm2 | 222 | 219 | |
| ECR | 192 (86.5) | 188 (85.8) | 0.6 (–5.9 to 7.2) |
| IACR-PTE | 178 (80.2) | 186 (84.9) | –4.8 (–11.9 to 2.4) |
| Lesion area >600–1000 cm2 | 87 | 70 | |
| ECR | 72 (82.8) | 59 (84.3) | –1.5 (–13.2 to 10.8) |
| IACR-PTE | 70 (80.5) | 57 (81.4) | –1.0 (–13.2 to 11.9) |
| Lesion area >1000 cm2 | 45 | 50 | |
| ECR | 33 (73.3) | 40 (80.0) | –6.7 (–24.0 to 10.5) |
| IACR-PTE | 37 (82.2) | 37 (74.0) | 8.2 (–8.9 to 24.8) |
Data are presented as No. (%) and are from the mITT population.
Abbreviations: CI, confidence interval; ECR, early clinical response; IACR, investigator-assessed clinical response; mITT, modified intent-to-treat; PTE, posttreatment evaluation.