Table 3.

Univariate associations between response phenotypes and regional genotypic scores of interest

Response phenotype	Genetic score	Coefficient	P value
Genotypic scores at the CD40 locus
∆SJC	RA score at CD40	0.07	0.0004
∆SJC	CD40 eQTL	0.06	0.002
∆SJC	CD40 mQTL	−0.05	0.009
∆ESR	RA score at CD40	0.05	0.01
∆ESR	CD40 eQTL	0.03	0.06
∆ESR	CD40 mQTL	−0.03	0.07
Genotypic scores for immune cell traits at the ENTPD1 locus
∆SJC	CD39 on CD4 T	−0.07	5e−05
∆SJC	mDC:%32+	−0.02	0.2
∆SJC	CD8:%39+	−0.06	0.001
∆SJC	CD4:%Treg(39+)	−0.07	0.0001
∆SJC	CD4:%Treg(39+73-)	−0.07	0.0001
∆SJC	CD4:%Treg(39+73+)	−0.07	0.0002
∆SJC	NKeff:%314−158a+	−0.04	0.02
∆SJC	CD4 T:%CD39+CD38+PD1−	−0.07	8e−05
∆ESR	CD39 on CD4 T	−0.003	0.9
∆ESR	mDC:%32+	−0.01	0.5
∆ESR	CD8:%39+	−0.008	0.7
∆ESR	CD4:%Treg(39+)	−0.004	0.8
∆ESR	CD4:%Treg(39+73−)	−0.004	0.8
∆ESR	CD4:%Treg(39+73+)	0.006	0.8
∆ESR	NKeff:%314−158a+	0.04	0.04
∆ESR	CD4 T:%CD39+CD38+PD1−	−0.004	0.8

The coefficients are the effect sizes of the standardised score on the standardised phenotype.

eQTL, expression quantitative trait loci; mTQL, methylation quantitative trait loci.ESR, erythrocyte sedimentation rate; RA, rheumatoid arthritis; SJC, swollen joint count;