Figure 2.

MNP-mediated cell manipulation strategies. (A) MNPs are injected intravenously into the animal and an external magnet is used to localize the particles at the injury site. Local cells at the injury site internalize MNPs via endocytosis. MNPs elicit local mechanical forces in response to external magnetic field stimulation, inducing axonal extension or glial cell migration into the lesion. (B) Cells are cultured in vitro and labeled with MNPs. These cells are then injected into the animal and guided to the injury site with an external magnet. Once in the lesion (red area), cells can release regenerative factors to promote regeneration.