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. 2019 Jul 25;7:179. doi: 10.3389/fbioe.2019.00179

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Copyright © 2019 Funnell, Balouch and Gilbert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Magnetic composite materials for supporting neural regeneration and non-invasive positioning. (A) MNPs embedded in a hydrogel can be aligned with a magnetic field and held in place as the gel solidifies. (B) MNP-loaded fibers can be aligned with a magnetic field and held in place as a gel solidifies. The MNPs can be functionalized with drugs, antibodies, nucleic acids, or fluorophores in either system. Naked MNPs can be loaded alongside drugs in the hydrogel or in the polymer fiber solution before electrospinning. Coaxial fibers with MNP-loaded core and drug-containing sheath can also be fabricated to offer magnetic alignment with tunable fiber nanotopography.