Table 1.
Overall Clinicopathologic Features of Microsatellite Instability-High (MSI-H) and Microsatellite Stable (MSS) Intestinal Carcinomas
| Characteristic | MSI-H, No. (%) (n = 115) | MSS, No. (%) (n = 41) | Total, No. (%) (n = 156) |
|---|---|---|---|
| Sex | |||
| Male | 55 (48) | 30 (73) | 85 (54) |
| Female | 60 (52) | 11 (27) | 71 (46) |
| Age (y), mean ± SD | 64 ± 16 | 62 ± 13 | 63 ± 15 |
| Location | |||
| Right colon | 85 (74) | 12 (29) | 97 (62) |
| Left colon | 13 (11) | 15 (37) | 28 (18) |
| Rectum | 11 (10) | 14 (34) | 25 (16) |
| Small bowel | 6 (5) | 0 (0) | 6 (4) |
| Histologic types | |||
| Adenocarcinoma, NOS | 79 (69) | 39 (95) | 118 (76) |
| Medullary | 14 (12) | 0 (0) | 14 (9) |
| Mucinous | 22 (19) | 2 (5) | 24 (15) |
| Tumor stage | |||
| I | 26 (23) | 7 (17) | 33 (21) |
| II | 53 (46) | 17 (42) | 70 (45) |
| III | 29 (25) | 13 (32) | 42 (27) |
| IV | 7 (6) | 3 (7) | 10(6) |
| Unknown | 0 (0) | 1 (2) | 1(1) |
| BRAF | |||
| Wild type | 60 (52) | — | — |
| Lynch | 29 (25) | — | — |
| Unknown | 31 (27) | — | — |
| Mutant (V600E) | 41 (36) | — | — |
| Unknown | 14 (12) | — | — |
NOS, not otherwise specified.