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. 2019 Jul 19;11(7):662. doi: 10.3390/v11070662

Figure 5.

Figure 5

FFV-infected cats exhibit early neurodegenerative changes in the central nervous system. (A) Neurons in the CNS of control cat N4 contain uniform, round nuclei, abundant basophilic Nissl substance, and are flanked by few glial cells (black arrow). Frontal lobe, Hematoxylin-eosin (HE) 400×. Scale bar = 100 µm. (B) Neurons in the CNS of FFV-infected cat FFV3 exhibit moderate satellitosis, characterized by increased numbers of glial cells (black arrows). Thalamus, HE 400×. Scale bar = 100 µm. (C) The meninges of FFV-infected cat FFV5 are expanded by minimal numbers of mature small lymphocytes (red arrows) and plasma cells (red arrowheads). Cerebellum, HE 400×. Scale bar = 100 μm. Neurons in the frontal lobe of this animal (inset) are shrunken, with hypereosinophilic cytoplasm, and exhibit moderate satellitosis (black arrows). Frontal lobe, HE 400×. (D) Neurons in the CNS of an FFV-infected cat are swollen and rounded, with an indistinct nucleus and a dispersed Nissl substance (chromatolysis). Thalamus, HE 400×. Scale bar = 100 µm.