Table 4.
Summary of pathological findings in glomeruli and tubulointerstitial compartment of control and FFV-infected cats. Kidney tissue was collected during necropsy on day 176 and submitted to the International Veterinary Renal Pathology Service for analysis. Cat FFV5 was on a different inoculation schedule than the rest of the FFV cats (Materials and Methods Section 2.2 and Figure 1).
| Analysis | Finding | N4 | FFV1 | FFV2 | FFV3 | FFV4 | FFV5 | Total Cats |
|---|---|---|---|---|---|---|---|---|
| Histology | Tubular degeneration (+/− atrophy) | - | + | + | - | - | - | 2 |
| TEM | Podocyte effacement | NT | +/+ | ++ | ++ | + | +++ | 5 |
| Cytoplasmic electron dense figures | NT | - | + | + | + | + | 4 | |
| Cytoplasmic myelin figures | NT | + | + | - | + | - | 3 | |
| Cytoplasmic vacuolization | NT | - | + | + | - | - | 2 | |
| Wrinkled glomerular capillary walls | NT | - | - | - | - | + | 1 |
+ = minimal, +/+ = minimal to mild, ++ = mild, +++ = moderate, NT = not tested.