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Sequence alignment of the regions of human immunodeficiency virus (HIV)-1 and SFVmac RT, showing the azido-3′deoxythymidine (AZT) resistance amino acid exchanges. The amino acids conferring AZT resistance are shown in red for HIV-1 (M41L, D67N, K70R, T215Y/F, K219E/Q) and blue for SFVmac RT (K211I, I224T, S345T, E350K), respectively. The amino acids of the polymerase active site are highlighted by an orange box. The amino acid identity is 26.2%.
