Table 2.
The analgesic effects of PE in hot-plate test assayed with Institute of Cancer Research (ICR) mice. The antinociceptive activity of PE was expressed as latency time (s), which indicates the heat tolerance of the experimental animals.
| Groups | Latency Time (s) | ||||
|---|---|---|---|---|---|
| 0 h | 0.5 h | 1 h | 2 h | 48 h | |
| BLANK | 11.55 ± 0.61 | 11.87 ± 0.85 | 11.23 ± 0.75 | 12.07 ± 0.75 | — |
| PE (200 mg/kg) | 12.37 ± 0.62 | 14.10 ± 0.65 | 16.98 ± 0.69 *** | 16.91 ± 1.10 *** | 12.49 ± 0.64 |
| PE (600 mg/kg) | 16.67 ± 1.19 | 27.64 ± 2.15 ### | 24.06 ± 1.56 # | 28.61 ± 2.41 ### | 17.69 ± 1.78 |
| Tramadol (20 mg/kg) | 12.50 ± 0.48 | 19.29 ± 1.21 §§§ | 19.02 ± 1.42 §§§ | 19.30 ± 1.28 §§§ | — |
Notes: Results are expressed as mean ± standard error of the mean (S.E.M, n = 8–10); # p < 0.01, *** p, ### p, §§§ p < 0.001 are considered significantly different to their respective control group at 0 h.