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. 2019 Jun 30;11(7):379. doi: 10.3390/toxins11070379

Figure 5.

Figure 5

LZ1 inhibits the pyruvate kinase activity and adenosine triphosphate (ATP) synthesis during plasmodium infection. (A) Schematic of glycolysis pathway. Metabolic enzymes are bolded. PK, pyruvate kinase. (B) LZ1 inhibits the pyruvate kinase activity of infected erythrocyte. (C) 2-deoxyglucose (2-DG) induces ATP reduction in uninfected erythrocyte. (D) 2-DG induces ATP reduction in infected erythrocyte. Data are presented as mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001, # p< 0.05, aa p < 0.01, aaa p < 0.001.