Figure 4.

An alignment of chromatin-binding sequences (CBS) and surrounding regions. CBSs of CoeEFV and ERV-Spuma-Spu are intact. The conserved tyrosine (Y; 4^th column) and arginine (R; 7^th column) residues in the CBS, which are essential for Gag mitotic chromosome binding and nuclear accumulation of Gag and genomic DNA [49,54,55], could be found in all viruses. The arginine-tyrosine-glycine (RYG) residues, which are also important for nuclear accumulation of FV Gag and DNA [55], were absent from CoeEFV and ERV-Spuma-Spu but could be found in all mammalian FVs.