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IOE administration increases GLUT4 expression and the phosphorylation of the PI3K signaling pathway intermediates in muscle. (A) GLUT4 expression was measured by western blotting of muscle lysates. (B) Phosphorylation of IRS, PI3K, and Akt in the muscle of db/db mice. All data are expressed as mean ± SD (n = 6). Values with different letters are significantly different; p < 0.05 (a > b > c).
