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IOE administration upregulates GLUT4 expression and activation of the PI3K signaling pathway in white adipose tissue (WAT). (A) Western blotting for GLUT4 protein expression in the WAT of db/db mice. (B) Phosphorylation of IRS, PI3K, and Akt and their total protein expression in the WAT of db/db mice. All data are expressed as mean ± SD (n = 6). Values with different letters are significantly different; p < 0.05 (a > b > c > d).
