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. 2019 Jul 21;9(7):1041. doi: 10.3390/nano9071041

Figure 4.

Figure 4

Figure 4

(a) Cell viability was assessed by MTT test after 24 h of exposure to increasing doses of different TiO2:SiO2 NPs. The white histogram represents control sample, dark grey bars represent dose 750 µg TiO2/mL, grey bar dose 75 µg TiO2/mL, and light grey bars dose 7.5 µg TiO2/mL. Data show the mean ± SE of at least three independent experiments. * Statistically significant with respect to control, p < 0.001; # Statistically different with respect to TiO2:SiO2 1:1 at dose 750 µg TiO2/mL, p < 0.001; § Statistically different with respect to TiO2:SiO2 1:3 at dose 750 µg TiO2/mL, p = 0.006. One-way ANOVA + Bonferroni’s post hoc test. (b) Hoechst 33342/propidium iodide (H/PI) staining of A549 treated for 24 h with different TiO2:SiO2 NPs (75 µg TiO2/mL). The histograms represent the percentage of viable (grey bars), necrotic (black bars), apoptotic (light grey bars), and mitotic (dashed bars) cells. Data show the mean ± SE of at least three independent experiments. * Statistically significant with respect to control according to one-way ANOVA + Bonferroni’s post hoc test; p < 0.05.