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. 2019 Jul 8;17(7):403. doi: 10.3390/md17070403

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Shows the protective effect of Casu injected into animals 10 min before the injection of native sPLA2 and edema induced by Casu alone. In (A), we also show the protective effect of naringenin (Nar) administered under the same conditions as Casu. This compound was used as an anti-inflammatory effect control. (B) Reveals the protective effective of Casu injected in the same manner as shown in (A). This figure shows that Casu injected 10 min after sPLA2 application neutralizes the myotoxic effects induced by sPLA2 once the CK levels decrease, revealing a histological similarity with saline. (C) Exhibits an irreversible profile of Casu, in which the enzymatic activity of sPLA2 is diminished in a dose-dependent manner.