Table 3. Summary of Findings for Barotrauma.
| Comparison | No. | Network Risk Ratio (95% CrI) | Anticipated Absolute Effecta | Quality of Evidence | ||
|---|---|---|---|---|---|---|
| Patients | Trials | With Intervention per 1000 | Difference (95% CrI) | |||
| LPV | NA | NA | 1 [Reference] | 68 | NA | NA |
| VV ECMO | 249 | 1 | 1.19 (0.24 to 5.88) | 81 | 13 (−52 to 332) | Moderate |
| HFOV | 608 | 2 | 1.69 (0.55 to 7.14) | 115 | 47 (−31 to 417) | Low |
| NMBA | 896 | 3 | 0.47 (0.18 to 1.03) | 32 | −36 (−56 to 2) | Low |
| Open lung strategyb | 3391 | 9 | 1.11 (0.54 to 1.84) | 75 | 7 (−31 to 57) | Low |
| Prone positioning | 506 | 2 | 0.78 (0.19 to 2.32) | 53 | −15 (−55 to 90) | Low |
| VV ECMO | NA | NA | 1 [Reference] | 145 | NA | NA |
| HFOV | NA | Indirect evidence | 1.35 (0.21 to 8.47) | 196 | 51 (−115 to 855) | Very low |
| NMBA | NA | Indirect evidence | 0.39 (0.07 to 1.86) | 56 | −89 (−135 to 125) | Very low |
| Open lung strategyb | NA | Indirect evidence | 0.94 (0.18 to 3.67) | 136 | −7 (−119 to 387) | Very low |
| Prone positioning | NA | Indirect evidence | 0.65 (0.08 to 3.55) | 94 | −51 (−133 to 370) | Very low |
| HFOV | NA | NA | 1 [Reference] | 134 | NA | NA |
| NMBA | NA | Indirect evidence | 0.29 (0.05 to 0.92) | 39 | −95 (−128 to −11) | Very low |
| Open lung strategyb | NA | Indirect evidence | 0.69 (0.14 to 1.88) | 92 | −42 (−115 to 118) | Very low |
| Prone positioning | NA | Indirect evidence | 0.48 (0.06 to 1.89) | 64 | −70 (−126 to 119) | Very low |
| NMBA | NA | NA | 1 [Reference] | 25 | NA | NA |
| Open lung strategyb | NA | Indirect evidence | 2.36 (0.79 to 6.91) | 59 | 34 (−5 to 148) | Very low |
| Prone positioning | NA | Indirect evidence | 1.66 (0.34 to 7.03) | 41 | 16 (−17 to 151) | Very low |
| Open lung strategyb | NA | NA | 1 [Reference] | 59 | NA | NA |
| Prone positioning | NA | Indirect evidence | 0.70 (0.17 to 2.61) | 41 | −18 (−49 to 95) | Very low |
Abbreviations: CrI, credible interval; HFOV, high-frequency oscillatory ventilation; LPV, lung protective ventilation; NA, not applicable; NMBA, neuromuscular blockade; VV ECMO, venovenous extracorporeal membrane oxygenation.
a
To compute anticipated absolute effect, risk ratio is less than or equal to 1 divided by event rate in the reference group (ie, 1/average control risk).
b
Open lung strategy using recruitment maneuver and/or higher positive end-expiratory pressure.