Table 1. Cohort Characteristics.
| Characteristic | No. (%) |
|---|---|
| No. of participants | 110 |
| Gestational age, mean (SD), wk | 38.4 (2.1) |
| Birth measurements, mean (SD) | |
| Head circumference, cm | 31.4 (3.7) |
| Weight, kg | 2.9 (0.6) |
| Length, cm | 47.5 (4.0) |
| Preterm | 12 (11) |
| Small for gestational agea | 35 (32) |
| History of neonatal intensive care unit | 38 (35) |
| Cesarean delivery | 64 (57) |
| Clinical findings | |
| Severe | 68 (62) |
| Mild or moderate | 6 (5) |
| No clinical findings | 36 (33) |
| Fetal brain destruction sequence | 50 (45) |
| Microcephaly | 54 (49) |
| Congenital contractures | 17 (15) |
| Neurologic symptoms at birth | 71 (65) |
| Abnormal examination findings | |
| Eye | 44 (40) |
| Hearing | 14 (13) |
| Prior transfontanelle ultrasonographyb | 100 (91) |
| Postnatal brain computed tomography | 81 (74) |
| Postnatal brain magnetic resonance imaging | 45 (41) |
| Both postnatal brain computed tomography and magnetic resonance imaging | 16 (15) |
| Age at computed tomography, median (IQR), d | 14 (3-124) |
| Age at magnetic resonance imaging, median (IQR), d | 31 (19-83) |
| Mothers with only PCR positive for Zika virus | 60 (55) |
| Infants with only PCR positive for Zika virus | 9 (8) |
| Mothers and infants both with PCR positive for Zika virus | 12 (11) |
Abbreviations: IQR, interquartile range; PCR, polymerase chain reaction.
a
Small for gestational age was defined as having a weight Z score less than −1.28 SDs for gestational age and sex at the time of birth.
b
Transfontanelle ultrasonography was not performed in 10 infants (9%). Two had normal computed tomography and/or magnetic resonance imaging findings and 8 had abnormal computed tomography and/or magnetic resonance imaging findings.