Table 1.
Hippocampal Genes Enriched in Both Control-SE and Astro-D2KO-SE
| Gene Symbol | Description | Control-SE | Astro-D2KO-SE | ||
|---|---|---|---|---|---|
| Rank | Fold | Rank | Fold | ||
| Npas4 | Neuronal PAS domain protein 4 | 1 | 46 | 3 | 23 |
| Hspa1b | Heat shock protein 1B | 2 | 37 | 1 | 28 |
| Hspa1a | Heat shock protein 1A | 3 | 36 | 2 | 26 |
| Fosb | FBJ osteosarcoma oncogene B | 4 | 27 | 5 | 18 |
| Fos | FBJ osteosarcoma oncogene | 5 | 18 | 6 | 14 |
| Inhba | Inhibin β-A | 6 | 17 | 13 | 9 |
| Ccl3 | Chemokine (C-C motif) ligand 3 | 7 | 16 | 4 | 22 |
| Egr1 | Early growth response 1 | 8 | 11 | 15 | 9 |
| Atf3 | Activating transcription factor 3 | 9 | 11 | 18 | 8 |
| Tnfrsf23 | Tumor necrosis factor receptor superfamily, member 23 | 10 | 11 | 21 | 7 |
| Egr4 | Early growth response 4 | 11 | 10 | 19 | 7 |
| Pcsk1 | Proprotein convertase subtilisin/kexin type 1 | 12 | 10 | 10 | 11 |
| Arc | Activity regulated cytoskeletal-associated protein | 13 | 9.4 | 24 | 6 |
| Nr4a1 | Nuclear receptor subfamily 4, group A, member 1 | 14 | 9.2 | 14 | 9.2 |
| Lilrb4 | Leukocyte immunoglobulin-like receptor, subfamily B, member 4 | 15 | 8.8 | 9 | 13 |
| Nr4a2 | Nuclear receptor subfamily 4, group A, member 2 | 19 | 7.6 | 7 | 13 |
| Serpinb2 | Serine (or cysteine) peptidase inhibitor, clade B, member 2 | — | — | 8 | 13 |
| Nts | Neurotensin | 27 | 6.1 | 11 | 10 |
| Gadd45g | Growth arrest and DNA-damage-inducible 45 γ | 20 | 7.0 | 12 | 10 |
Differential expression was at P < 0.01 and a fold change ≥3 or ≤−3 in control-SE (n = 4) and Astro-D2KO-SE (n = 4) hippocampus.