Table 2.
Individual Transcripts Affected by SE in Hippocampus of Control-SE Mice
| Gene Symbol | Description | Fold Change | P |
|---|---|---|---|
| Genes Modified in Control-SE Hippocampus Only | |||
| Angiogenesis | |||
| n-R5s87 | Nuclear encoded rRNA 5S 87 | 3.46 | 0.003093 |
| Mir128-2 | microRNA 128-2 | 2.19 | 0.001731 |
| Cell cycle and proliferation | |||
| Cks2 | CDC28 protein kinase regulatory subunit 2; cyclin-dependent kinases regulatory subunit 2-like; predicted gene 12891; predicted gene 15452 | 2.73 | 0.002548 |
| Mnd1 | Meiotic nuclear divisions 1 homolog (Saccharomyces cerevisiae) | 2.62 | 0.002064 |
| Mir136 | microRNA 136; mmu-mir-136; mmu-mir-3071 | 2.2 | 0.006001 |
| Lcmt2 | Leucine carboxyl methyltransferase 2 | 2.19 | 0.004942 |
| Cdk6 | Cyclin-dependent kinase 6 | 2.15 | 0.008803 |
| Mir708 | microRNA 708 | 2.13 | 0.000156 |
| Cell death mechanisms | |||
| Mir376a | microRNA 376a | 2.32 | 0.009128 |
| Enzymes | |||
| Acat3 | Acetyl-coenzyme A acetyltransferase 3 | 2.59 | 0.002661 |
| Nanp | N-acetylneuraminic acid phosphatase | −2.17 | 0.001961 |
| Mitochondrial function | |||
| mt-Tk | Mitochondrially encoded tRNA lysine | 6.39 | 0.002554 |
| mt-Tt | Mitochondrially encoded tRNA threonine | 4.81 | 0.001726 |
| mt-Tt | Mitochondrially encoded tRNA threonine | 4.64 | 0.002216 |
| mt-Ts2 | Mitochondrially encoded tRNA serine 2; mitochondrially encoded tRNA leucine 2 | 3.85 | 0.003586 |
| mt-Ts2 | Mitochondrially encoded tRNA serine 2 | 3.29 | 0.007613 |
| mt-Ty | Mitochondrially encoded tRNA tyrosine | 2.1 | 0.00825 |
| Histones | |||
| Hist2h3b | Histone cluster 2, H3b; histone cluster 1, H3e; histone cluster 1, H3b; histone cluster 1, H3d; histone cluster 1, H3c; histone cluster 1, H3f; histone cluster 2, H3c2; histone cluster 2, H3c1 | 3.32 | 0.004662 |
| Hist1h3d | Histone cluster 1, H3d | 2.03 | 0.000865 |
| Inflammation | |||
| Stk40 | Serine/threonine kinase 40 | 2.77 | 0.00856 |
| Extracellular matrix | |||
| Gm13034 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 pseudogene | 2.53 | 0.000736 |
| Tinag | Tubulointerstitial nephritis antigen | 2.34 | 0.006487 |
| Dsp | Desmoplakin | −3.49 | 0.002388 |
| Glt8d2 | Glycosyltransferase 8 domain containing 2 | −2.09 | 0.000497 |
| Neural plasticity | |||
| Emp1 | Epithelial membrane protein 1 | 3.25 | 0.00215 |
| Neuroprotective mechanisms | |||
| Dnajb5 | DnaJ (Hsp40) homolog, subfamily B, member 5 | 2.12 | 0.00161 |
| Snord14e | Small nucleolar RNA, C/D box 14E; heat shock protein 8 | 2.01 | 0.001037 |
| Neurotransmitter signaling | |||
| Sstr2 | Somatostatin receptor 2 | 2.31 | 0.007373 |
| Gucy2c | Guanylate cyclase 2c | 2.16 | 0.002788 |
| Dok5 | Docking protein 5 | 2.08 | 0.004218 |
| Per2 | Period circadian clock 2 | 2.04 | 0.002296 |
| Ttc26 | Tetratricopeptide repeat domain 26 | −2.12 | 0.006375 |
| Ttc26 | Tetratricopeptide repeat domain 26 | −2.12 | 0.006375 |
| Slc22a8 | Solute carrier family 22 (organic anion transporter), member 8 | −2.45 | 0.007346 |
| Transcription factors | |||
| Hes5 | Hairy and enhancer of split 5 (Drosophila) | −2 | 0.001097 |
Differential expression was at a P < 0.01 and a fold change ≥2 or ≤−2 in control-SE (n = 4) hippocampus.