Table 3.
Individual Transcripts Affected by SE in Hippocampus of Astro-D2KO-SE Mice
| Gene Symbol | Description | Fold Change | P |
|---|---|---|---|
| Genes Modified in Astro-D2KO-SE Hippocampus Only | |||
| Apoptosis | |||
| Mir128-1 | microRNA 128-1 | 2.17 | 0.00109 |
| Enzymes | |||
| Arxes1 | Adipocyte-related X-chromosome expressed sequence 1; adipocyte-related X-chromosome expressed sequence 2 | 2.05 | 0.000814 |
| B3gnt5 | UDP-GlcNAc: β Gal β-1,3-N-acetylglucosaminyltransferase 5 | 2.03 | 0.000779 |
| Pi15 | Peptidase inhibitor 15 | 2 | 0.001314 |
| Nt5c1a | 5-nucleotidase, cytosolic IA | 2 | 0.001601 |
| Aspa | Aspartoacylase | −2.03 | 0.004198 |
| Extracellular matrix | |||
| Grem2 | gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis) | 2.67 | 0.000002 |
| Hs3st5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | 2.08 | 0.00285 |
| Inflammation | |||
| Serpinb2 | Serine (or cysteine) peptidase inhibitor, clade B, member 2 | 13.01 | 0.000372 |
| Ctla2a | Cytotoxic T lymphocyte-associated protein 2 α | 2.6 | 0.00251 |
| Msr1 | Macrophage scavenger receptor 1 | 2.04 | 0.003938 |
| Il11 | Interleukin 11 | 2.02 | 0.007672 |
| Sbno2 | Strawberry notch homolog 2 (Drosophila) | 2.4 | 0.007635 |
| Membrane transporters | |||
| Slc10a6 | Solute carrier family 10 (sodium/bile acid cotransporter family), member 6 | 2.18 | 0.007324 |
| Neural plasticity | |||
| Zfp804a | Zinc finger protein 804A | 2.46 | 0.002032 |
| Gdnf | Glial cell line derived neurotrophic factor | 2.03 | 0.001031 |
| Mir344e | microRNA 344e | −2.36 | 0.000517 |
| Ptch1 | Patched homolog 1 | −2.13 | 0.000437 |
| Neurotransmitter signaling | |||
| Penk | Preproenkephalin; short chain dehydrogenase/reductase family 39U, member 1 | 2.47 | 0.004063 |
| Gfra1 | Glial cell line derived neurotrophic factor family receptor α 1 | 2.43 | 0.002592 |
| Smim3 | Small integral membrane protein 3 | 2.22 | 0.00379 |
| Other | |||
| Ccdc138 | Coiled-coil domain containing 138 | 2.22 | 0.008305 |
| Snord107 | Small nucleolar RNA, C/D box 107; SNRPN upstream reading frame | −2.38 | 0.001387 |
| Mir1839 | microRNA 1839; RIKEN cDNA 2900076A07 gene | −2.18 | 0.005299 |
| Oxidative stress | |||
| Gpx8 | Glutathione peroxidase 8 (putative) | 2.19 | 0.001493 |
| Transcription factor | |||
| Osr1 | Odd-skipped related 1 (Drosophila) | −2.01 | 0.001485 |
Differential expression was at P < 0.01 and a fold change ≥2 or ≤−2 in Astro-D2KO-SE (n = 4) hippocampus.