Table 4.

GSEA of Genes Affected by SE in Control vs Astro-D2KO Mice

Gene Ontology	Description	Total No. Genes in Set	ES	NES	Nominal P	FDR q Value
Enriched in control-SE animals
GO:0006979	Response to oxidative stress	40	−0.39	−1.35	0	0.276
GO:0019932	Second-messenger–mediated signaling	140	−0.47	−1.34	0	0.276
GO:0007267	Cell–cell signaling	369	−0.42	−1.35	0	0.277
GO:0045597	Positive regulation of cell differentiation	24	−0.68	−1.36	0	0.279
GO:0009991	Response to extracellular stimulus	33	−0.65	−1.37	0	0.281
GO:0019725	Cellular homeostasis	133	−0.48	−1.37	0	0.281
GO:0009887	Organ morphogenesis	139	−0.43	−1.37	0	0.282
GO:0048878	Chemical homeostasis	139	−0.48	−1.37	0	0.284
GO:0008284	Positive regulation of cell proliferation	128	−0.49	−1.38	0	0.291
GO:0030234	Enzyme regulator activity	294	−0.36	−1.38	0	0.292
Enriched in AstroD2KO-SE animals
GO:0016772	Transferase activity transferring phosphorus-containing groups	392	−0.26	−1.26	0	0.366
GO:0004672	Protein kinase activity	261	−0.31	−1.3	0	0.371
GO:0051239	Regulation of multicellular organismal process	139	−0.45	−1.29	0	0.373
GO:0016301	Kinase activity	340	−0.27	−1.29	0	0.376
GO:0016773	Phosphotransferase activity alcohol group as acceptor	309	−0.29	−1.31	0	0.38
GO:0000122	Negative regulation of transcription from RNA polymerase II promoter	72	−0.37	−1.34	0	0.381
GO:0009607	Response to biotic stimulus	95	−0.55	−1.34	0	0.384
GO:0031667	Response to nutrient levels	29	−0.64	−1.32	0	0.385
GO:0006937	Regulation of muscle contraction	17	−0.58	−1.3	0	0.385
GO:0008283	Cell proliferation	470	−0.44	−1.31	0	0.387

Comparison of [control (n = 4) vs control-SE (n = 4)] vs [Astro-D2KO (n = 4) vs Astro-D2KO-SE (n = 4)] animals at a nominal P < 0.01.

Abbreviations: ES, enrichment score; NES, normalized enrichment score.