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. 2019 Jun 26;38(15):e95874. doi: 10.15252/embj.201695874

Figure 3. Hierarchical clustering of the most informative proteins, correlation with TCGA and RNAseq data.

Figure 3

  • A–D
    Proteins needed to distinguish between sensitive and resistant cells in cytoplasm (A), secretome (B) and nucleus with bootstrap analysis (C), of the 15 candidates in cell pellets (D).
  • E, F
    Heatmap of the 15 candidates with RNAseq data of S1, S2 R1–4 and a second cohort.
  • G
    Correlation matrix of the 15 candidates with TCGA, numbers indicate Pearson correlation coefficient.
  • H
    Heatmap of Verfaillie signature with RNAseq data correlating invasive (i)/proliferative (p) phenotype with resistant/sensitive melanoma cell cultures.
  • I
    Bar graph of 1st cohort (sn, ne) and 2nd cohort (AR; all resistant) correlating the Verfaillie signature of invasive (i) and proliferative (p) genes with the protein expression up or downregulated in resistant cell cultures.
  • J
    Bootstrap analysis with AU value of 1st and 2nd proteome and RNA cohort versus proteome signature (15 proteins) and RNA signature of the Verfaillie publication, + multiparameter correction.