Table 1.
Category of primary cells and the IC50 to MAPKi treatment
| IC50 LGX (nM) | IC50 PLX (nM) | IC50 MEK162 (nM) | |
|---|---|---|---|
| Sensitive BRAF mutated | |||
| MM000921 (S1) | 3 | 210 | 50 |
| MM980513 (S2) | 1 | 100 | 10 |
| MM990922 | 10 | 1,032 | 100 |
| MM991104 | 3 | 200 | 100 |
| MM951004 | 7 | 413 | 100 |
| MM990802 | 3 | 176 | 20 |
| MM990706 | 2 | 137 | 10 |
| BRAF mut | |||
| MM130604 (R2) | 1,980 | 520 | 20 |
| MM130820 (R3) | 80 | 2,690 | 20 |
| BRAF/NRAS mut | |||
| MM140307 (DR1) | 200 | > 10,000 | > 1,000 |
| MM121224 (R1)/DMSO | 980 | 3,960 | 100 |
| MM140906 (DR2) | >200 | > 10,000 | > 1,000 |
| MM121224_250 nM MEK162 | 980 | 3,960 | > 10,000 |
| MM121224_500 nM MEK162 | 980 | 3,960 | 1,924 |
| MM130903 (R4) | 3,220 | 970 | 20 |
| MM150423 (DR 3) | 554 | > 10,000 | 1,000 |
| Intrinsic resistant | |||
| MM111031 (IR) | 1670 | 140 | 30 |
| MM150325 | 8*107 | 8*106 | 951.3 |
| MM150405 | 13,321.5 | 36,954 | 5,663 |