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. 2019 Jul 23;93(4):e322–e333. doi: 10.1212/WNL.0000000000007831

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Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cognitive responses are plotted over time for each β-amyloid (Aβ) group, in each cohort separately: (A) Alzheimer's Disease Neuroimaging Initiative (ADNI), (B) Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably (BioFINDER), and (C) Australian Imaging, Biomarkers & Lifestyle (AIBL). Individual Preclinical Alzheimer's Cognitive Composite (PACC) components are shown as well as the PACC in the bottom row. Akaike information criterion and p values are shown in each plot, testing for differences between Aβ groups over time. dMemory = Logical Memory Delayed Recall; MMSE = Mini-Mental State Examination; Trails B = Trail-Making Test B.