Table 1.
Key features of MARCH proteins.
| Name | Localization | Expression | Function | References |
|---|---|---|---|---|
| MARCH1 (RNF171) | Lysosome endosome | Secondary lymphoid B cell monocyte immature DC | DC maturation Antigen presentation Insulin resistance | (14, 15, 22, 25, 30–35) |
| MARCH2 (RNF172) | ER Endosome lysosome Plasma membrane | Ubiquitous | Immune response autophagy Endosomal trafficking | (15–17, 36–38) |
| MARCH3 (RNF173) | Endosome lysosome Plasma membrane | Ubiquitous | Inflammation | (15, 17, 26) |
| MARCH4 (RNF174) | Golgi | Lung Brain Placenta | Immune regulation | (15) |
| MARCH5 (RNF153, MITOL) | Mitochondria | Ubiquitous | Mitochondrial morphology ESC pluripotency Innate immunity | (27, 28, 39–42) |
| MARCH6 (RNF176, TEB4) | ER | Ubiquitous | ERAD | (18, 43) |
| MARCH7 (RNF177, AXOT) | Cytoplasm Nucleus Plasma membrane | Ubiquitous | Inflammation T cell development Antigen presentation | (12, 44–48) |
| MARCH8 (RNF178, c-MIR) | Endosome lysosome Plasma membrane nucleus | Ubiquitous | Inflammation T cell development Antigen presentation | (4, 15, 19, 49–53) |
| MARCH9 (RNF179) | TGN Lysosome | Lung Lymph node Spleen T, B, DC | Immune regulation | (20–22, 39) |
| MARCH10 (RNF190) | Cytoplasm | Ubiquitous | Spermatogenesis | (29, 39) |
| MARCH11 (RNF226) | MVB TGN | Testis | Spermatogenesis | (11) |