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. 2019 Jun 27;13(8):1763–1777. doi: 10.1002/1878-0261.12526

Figure 4.

Figure 4

Kaplan–Meier analysis of combinatory PSA and Ki67 IR scores of primary tumor samples in relation to cancer‐specific survival after treatment with ADT in metastatic MetA‐C patient cohort (A) and in a validation cohort of TUR‐P‐diagnosed patients (B). PSA IR was dichotomized as above (high) or below (low) median and Ki67 as quartile 4 (high) or below (low), using cutoff values for the corresponding cohorts. (A) Patients with high PSA, low Ki67 primary tumor IR show significantly longer cancer‐specific survival after first ADT than other patients. (B) Patients with high PSA, low Ki67 show longer and patients with low PSA, high Ki67 show shorter cancer‐specific survival after first ADT compared to other patients. (C–D) Multivariate Cox analysis shows that the combinatory PSA, Ki67 IR scores of primary tumors add prognostic value to GS in metastatic (C) and TUR‐P (D) patient cohorts.