Table 3.
List of Nonsynonymous Mutations that Differed between at Least One of the A-Series Strains and a Sequence Type–matched, Non–Cystic Fibrosis Strain, or among Strains Harvested from a Single Patient
| Isolate | Number of NSMs | Implicated Genes and Pathways |
|---|---|---|
| A vs. reference | 80 | Adhesion (sdrC, fnbpb) |
| DNA replication and repair (gyrA, addA, recN) | ||
| Metabolism (adhE, sufS, trpG, ilvB, hisA, deoD, purl, rny, malX, araB, tktA, pckA, nagB, rpoB, mvaK2, malA, dagK) | ||
| Post-translational processing and proteolysis (pepF, pepA2, pepX, aur, ureE) | ||
| Redox homeostasis (hmp, ndhF) | ||
| Structural homeostasis (tagE, tagH, fmt, ebh, pbp3, lytH) | ||
| Transcriptional regulation (arlS, malR, kdpD, licR) | ||
| Translation (prfB, miaA, leuS, rumA, rplX, rpmH) | ||
| Transport (uhpT, oppA, ykoD, potA, kdpA, kdpB, corA, nark, copA, rarD_2) | ||
| Other (hemC, hssS) | ||
| Unknown (ybaB, comFC) | ||
| A | 27 | Adhesion (fnbpb, sdrE, ebhA) |
| Metabolism (rpoB, mvaK2, malA, dagK, argF, gdpP, dacA, phoA, carB, bglK, tagE, glmM, lqo) | ||
| Post-translational processing (ureE) | ||
| Transcriptional regulation (licR, saeR, rsbV, bglG) | ||
| Translation (rpmH, rpsJ) | ||
| Transport (gsiC) | ||
| B | 17 | fadN, metG, hisC, nikE, lysC, recD2, acsA, liar, smc, leuA, rpsJ |
| C | 27 | hutH, ggt, oxyR, tagO, uvrA, mecA, purS, carB, pyrF, lapB, mnmA, ezrA, mrcA, artQ, ebh, rplC, rspJ, sarR, dapF, gntT, oatA |
Definition of abbreviation: NSMs = nonsynonymous mutations.