. 2019 Aug;61(2):150–161. doi: 10.1165/rcmb.2019-0191ST

Table 1.

Lymphocytes

Population	Murine Markers	Human Markers	References
CD4⁺ T cell	Low SSC, CD3ε⁺ or TCRαβ or γδ⁺, CD4⁺	—
CD8⁺ T cell	Low SSC, CD3ε⁺ or TCRαβ or γδ⁺, CD8⁺	—
CD4⁺ Treg cell	CD4⁺ T cell expressing Foxp3-transgenic fluorochrome, CD25^hi	CD4⁺ T cell, CD127^lo, CD25^hi; intra-nuclear staining for FOXP3	10, 53, 54
Effector T cell	CD4⁺ or CD8⁺ T cell, CD62L^loCD44^hi, CD69^hi	See below	55, 56
Naive T cell	CD4⁺ or CD8⁺ T cell, CD62L^hiCD44^lo, CD69^lo	CD4⁺ or CD8⁺ T cell, CCR7^hiCD45RA^hi	55–60
Effector-memory T cell	—	CCR7^loCD45RA^lo
Central-memory T cell	—	CCR7^hiCD45RA^lo
T helper subset	Generally defined by transcription factor and cytokine staining (see text for examples)	—
CD4⁺ tissue-resident memory T cells	CD4⁺ T cell, CD11a⁺CD69⁺	—	61–64
CD8⁺ tissue-resident memory T cells	CD8⁺ T cell, CD103⁺CD69⁺	—

Definition of abbreviations: SSC = side scatter; Treg = regulatory T.