FIGURE 3.

Study 2: plasma arginine and citrulline concentrations (A) and fluxes (B), NO production (C), and phenylalanine and tyrosine fluxes and the phenylalanine-to-tyrosine conversion (D) in male mice treated with ADI-PEG20 (n = 10, represented by squares) or saline (n = 9, represented by circles) after endotoxin (LPS) challenge. Values are means ± SEs. Individual values are also shown. ^‡Arginine flux was not determined in ADI-PEG20 mice due to arginine depletion. **P < 0.01. ADI-PEG20, pegylated arginine deiminase.