Fig. 3.

Relationship between haemoglobin at baseline and day 7 as a fractional change and b absolute change. One thousand two hundred twenty-two patients were treated with chloroquine (CQ) alone and 539 with chloroquine plus primaquine (CQ+PQ). The open circle represents the single patient with a clinically significant fall > 25% to < 7 g/dL at day 7 (female patient with normal G6PD status). The dashed orange line represents a fractional fall of 25%. The baseline Hb correlated negatively with the fractional change in Hb at day 7 (r = − 0.521 [95% CI − 0.554 to − 0.486], p < 0.0001)