Table 3.
Values of the most influential COI model inputs
| Input | Value | Reference |
|---|---|---|
| Population inputs | ||
| Number of specialist paediatric reviews per patient per year | 1 | NHS Wolfram Syndrome Service (Birmingham Children’s Hospital), 2016 [16] |
| DM: management | ||
| Paediatric outpatient diabetes care, average annual cost | £2925.00 | NHS National Tariff 2016-2017 [20] |
| Proportion of patients managed by continuous subcutaneous insulin infusions | 0.19 | Diabetes UK, 2012 [7] |
| Insulin treatment, continuous subcutaneous insulin infusions, average annual cost of consumables | £2863.85 | Cummins et al. 2010 [15] |
| Insulin treatment, multiple daily injections, average annual cost of consumables | £984.10 | Cummins et al. 2010 [15] |
| DM: complications | ||
| Incidence of end-stage renal disease | 0.31 | Pratoomsoot et la. 2009 [10] |
| Haemodialysis, average annual cost | £35,352.31 | Roze et al. 2005 [26] |
| Kidney transplant, average cost per first year | £27,795.98 | Roze et al. 2005 [26] |
| Peritoneal dialysis, average annual cost | £26,543.77 | Roze et al. 2005 [26] |
| Incidence of myocardial infarction | 0.32 | Pratoomsoot et la. 2009 [10] |
| Myocardial infarction, average cost in year of event | £6234.64 | Roze et al. 2005 [26] |
| Hearing impairment | ||
| Proportion of patients with sensorineural hearing loss | 0.66 | Barrett et al. 1995 [2] |
| Proportion of patients with sensorineural hearing loss requiring cochlear implants | 0.17 | Karzon et al. 2013 [11] |
| Cochlear implants, bilateral, average cost (management) | £31,481.77 | NHS Reference Costs 2015–2016 [19] |
| Visual impairment | ||
| Number of ophthalmology reviews at local centre after symptom onset, per year | 2.00 | Patient experience (Wolfram Focus Group), 2016 [30] |
| Number of occupational therapist visits for low vision services | 6.00 | Warren 1995 [28] |
| Cost of occupational therapist visit | £131.02 | NHS Reference Costs 2015–2016 [19] |
| Retinal photography, average cost | £174.16 | NHS Reference Costs 2015–2016 [19] |
| Renal/neurogenic bladder | ||
| Proportion of patients with neurogenic bladder | 0.55 | Barrett et al. 1995 [2] |
| Intermittent self-catheterisation, mean annual cost | £2771.58 | NCGC Infection prevention and control, 2012 [12] |
DM diabetes mellitus, NCGC National Clinical Guideline Centre, NHS National Health Service