Table 3.
Cardiovascular mortality associated with quintiles of serum uric acid in unadjusted and multivariable-adjusted Cox models
| Variants | Event | Unadjusted Model 1 | P value | Multivariable adjusted Model 2 | P value | Multivariable adjusted Model 3 | P value |
|---|---|---|---|---|---|---|---|
| Quintile of uric acid level (mg/dL) | 408/9405 (4.0) | ||||||
| Q1(< 6.06) | 131/1865 (7.0) | 1.667 (1.265–2.197) | <0.001 | 1.327 (0.986–1.786) | 0.062 | 1.166 (0.820–1.657) | 0.392 |
| Q2(6.06–6.67) | 114/1877 (6.0) | 1.341 (1.010–1.782) | 0.043 | 1.268 (0.942–1.706) | 0.118 | 1.311 (0.932–1.843) | 0.120 |
| Q3 (6.68–7.27) | 82/1892 (4.3) | Reference | Reference | Reference | |||
| Q4 (7.28–8.03) | 86/1878 (4.6) | 1.152 (0.851–1.559) | 0.359 | 1.088 (0.791–1.497) | 0.602 | 1.146 (0.796–1.648) | 0.463 |
| Q5 (≥8.04) | 102/1893 (5.4) | 1.555 (1.162–2.080) | 0.003 | 1.259 (0.916–1.731) | 0.156 | 1.144 (0.786–1.665) | 0.482 |
Note: Reference group is Q3 group (6.68–7.27 mg/dL). Values are presented as number (%) of events or hazard ratio (95% confidence interval). Q, quintile
Model 1 are unadjusted. Model 2 are adjusted for the factors of age, sex, body mass index. Model 3 are adjusted for the factors of model 1 covariates and diabetes mellitus, cardiovascular disease, residual renal function, hemoglobin, serum albumin, serum potassium, serum natrium, serum phosphorus, serum calcium, serum parathyroid hormone, serum creatinine, and fasting plasma glucose