Table 1.
A Summary of Studies about Excipients Intolerance
| Author (Reference) | medicine name | allergen | clinical manifestation of anaphylaxis |
|---|---|---|---|
| Barni et al. [19] | benzathine benzylpenicillin | soy | an itching papular rash |
| Barbaud et al. [20] | pills containing paracetamol and a non-steroidal anti-inflammatory drug | carboxymethylcellulose | eczematous rashes |
| pills containingpiroxicam and carboxymethylcellulose | carboxymethylcellulose | a maculopapular rash in the trunk | |
| pills containing levothyroxine and carboxymethylcellulose | carboxymethylcellulose | a chronic generalized urticaria | |
| Bigliardi et al. [21] | Xyloneural and Kenacort® A 40 | carboxymethylcellulose | generalized pruritus, urticaria, angioedema in the lips, tachycardia and hypotonia |
| carbostesin and Triamcort-Depot® | carboxymethylcellulose | a generalized urticaria, angioedema in the lips, dizziness and breathing problems | |
| lidocaine and Diprophos® | carboxymethylcellulose | sweating, flush with generalized pruritus, nausea and angioedema in the feet and in the lips | |
| Bircher et al. [22] | lidocaine and Kenacort A10 | carboxymethylcellulose | nausea, sweating, thoracic oppression, pruritus, generalized urticaria, and hypotension |
| Caliskaner et al. [23] | rifampicin | patent blue V (PBV) | macular, itchy rashes in the face, ears, buttocks, elbows and knees |
| Duenas-Laita et al. [24] | a generic omeprazole capsule | soybean oil | hypotension and difficulty breathing |
| Field et al. [25] | triamcinolone acetate | carboxymethylcellulose | a rash, urticaria and associated periorbital angioedema |
| Gooch et al. [26] | warfarin | one of the dyes | recurrent, pruritic maculopapular rashes in the trunk and upper limbs |
| Koppel et al. [27] | tegretol | FD&C Red 40 | rhinorrhea, tearing, and nasal stuffiness |
| Laing et al. [28] | triamcinolone acetonide | carboxymethylcellulose | lip swelling, wheezing, and an urticarial rash |
| Millar et al. [29] | erythromycin | the colouring agent E110 | some tingling and swelling in the fingers and feet |
| Moneret-Vautrin et al. [30] | althesin | anti-cremophor EL IgG STS antibodies | cyanosis, an erythema in the whole trunk |
| Mumoli et al. [31] | furosemide | croscarmellose sodium | an erythematous cutaneous rash with diffuse itching |
| Rogkakou et al. [32] | ferrous sulphate | orange disperse (Sunset Yellow) | a severe facial erythema with itching and skin oedema |
| Rubinger et al. [33] | prednisone | acacia | itching with rash and fever |
| prednisone | tragacanth | itching with a rash | |
| prednisone | refused to be tested | itching with arthralgia | |
| Sims-McCallum et al. [34] | 6-Mercaptopurine Tablets | cornstarch | a red maculopapular rash in the chest, back, and arms with slightly pruritic |
| van Hooff et al. [35] | cyclosporin | the solvent | headache, erythema in the head, oedema in the conjunctivae, high blood pressure, and tachycardia |