Table 6.
Highly upregulated proteins in EVs isolated from stimulated whole saliva of pSS patients
| Number | Gene | Related protein* | Classification and function** |
|---|---|---|---|
| Non-SS vs. pSS | |||
| 1 | CD44 | CD44 antigen | FOXP3 expression and regulatory T-cell suppression, promotes tumour growth |
| 2 | MVP | Major vault protein | IFNγ-mediated signalling, MAP kinase activity, neutrophil degranulation |
| 3 | NGAL | Neutrophil gelatinase-associated lipocalin | Innate immunity, tumour-associated antigen, cell adhesion |
| Controls vs. pSS | |||
| 1 | FCN1 | Ficolin-1 | Pattern-recognition receptor in innate immunity, complement activation |
| 2 | CD44 | CD44 antigen | FOXP3 expression and regulatory T-cell suppression, promotes tumour growth |
| 3 | ANXA4 | Annexin A4 | NF-kappaB binding, apoptosis, IL-8 secretion |
*The three most upregulated immunological proteins in whole saliva of pSS patients deviating in replicates i.e. number of individuals (frequency), and spectral counts, as identified by proteomics analysis and Scaffold (v 4.4.6, http://www.proteomesoftware.com/products/scaffold/)
**The classification and functions of the proteins presented were identified using publicly available databases, such as UniProt (http://www.uniprot.org)