Table 5.

Comparison of the pharmacokinetics of irinotecan and SN-38

	TANDEM-IRI	FOLFIRI	P value
AUC of irinotecan (hr*ng/ml)	4327.1 ± 2919.1	8958.1 ± 4484.1	N.S.
AUC/Dose of irinotecan	37.8 ± 12.8	36.9 ± 17.0	N.S
AUC of SN-38 (hr*ng/ml)	269.9 ± 148.3	165.7 ± 90.3	N.S
AUC/Dose of SN-38	3.01 ± 1.87	0.68 ± 0.36	0.009
Cmax of irinotecan (hr*ng/ml)	624.7 ± 469.7	1626.0 ± 264.1	<  0.001
Cmax/Dose of irinotecan	5.4 ± 2.4	6.8 ± 1.2	N.S
Cmax of SN-38 (hr*ng/ml)	30.4 ± 17.1	18.8 ± 6.3	N.S
Cmax/Dose of SN-38	0.32 ± 0.11	0.08 ± 0.03	<  0.001