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. 2019 Jun 19;39(25):4874–4888. doi: 10.1523/JNEUROSCI.2772-18.2019

Figure 2.

Figure 2.

OVX decreases the mEPSC but not mIPSC frequency of layer 5 pyramidal neurons in somatosensory cortex. A, Representative traces of mEPSCs recorded from layer 5 pyramidal neurons in somatosensory cortex and occipital cortex. The population bar graphs show the mean frequency and amplitude of mEPSCs from sham and OVX mice (n = 5 mice for each group; somatosensory cortex: 7 sham cells and 7 OVX cells, p = 0.044 and t = 2.244 for frequency, p = 0.626 and t = 0.471 for amplitude, df = 12; occipital cortex: 8 sham cells and 7 OVX cells, p = 0.734 and t = 0.347 for frequency, p = 0.060 and t = 2.061 for amplitude, df = 13). Unpaired two-tailed Student's t test. *p < 0.05. B, Representative traces showing that mIPSCs recorded from layer 5 pyramidal neurons in somatosensory cortex and occipital cortex are not altered by sham or ovariectomy surgery. Bar graphs show the frequency (somatosensory cortex: 12 sham cells and 10 OVX cells, p = 0.113, t = −1.248, df = 20; occipital cortex: 9 sham cells and 7 OVX cells, p = 0.097, t = −1.363, df = 14) and amplitude (somatosensory cortex: p = 0.417, t = −0.213; occipital cortex: p = 0.172, t = −0.978) of mIPSCs between sham and OVX mice (n = 5 mice for each group). Unpaired two-tailed t test with p > 0.05 as nonsignificant.