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. 2008 Jun 4;28(23):5891–5900. doi: 10.1523/JNEUROSCI.5187-07.2008

Figure 5.

Figure 5.

The myelination defect correlates with abnormal levels of expression of several genes involved in Schwann cell differentiation or proliferation. The mRNA levels were determined by RT-PCR analysis on samples of sciatic nerves at P4, P17, and P20. The graphs show the ratios of mRNA levels in homozygous mutant versus wild-type animals, presented as fold increase or decrease. A, The expression of a first subset of genes is increased in mutant compared with wild-type animals. The ratios superior to the threshold of twofold (indicated by the top red line) were considered significant. B, For a second subset of genes, the expression is decreased in mutant compared with wild-type animals. The ratios superior to the threshold of twofold (indicated by the lower red line) were considered significant. C, A last subset of genes showed only limited variations in expression. Error bars indicate SEM.