Table 5.
Main effects of microstimulation
| 1 Hz |
2 Hz |
5 Hz |
10 Hz |
|||||
|---|---|---|---|---|---|---|---|---|
| Dec | Inc | Dec | Inc | Dec | Inc | Dec | Inc | |
| CTX → CTX | ||||||||
| Normal | ||||||||
| %Respond | 12.5 | 2.3 | 29.9 | 5.3 | 49.6 | 3.4 | 19.7 | 0.4 |
| Latency (ms) | 125 | 75 | 125 | 75 | 100 | 75 | 60 | 60 |
| Duration (ms) | 200 | 50 | 225 | 50 | >200 | 50 | >100 | 30 |
| MPTP | ||||||||
| %Respond | 16.6 | 6.9/10.1a | 31.8 | 6.5/9.7a | 45.6 | 10.6 | 20.2 | 5.5 |
| Latency (ms) | 150 | 75/250a | 125 | 75/275a | 125 | 75 | 90 | 60 |
| Duration (ms) | 200 | 50/275a | 250 | 50/100a | >200 | 50 | >100 | 30 |
| GP → CTX | ||||||||
| Normal | ||||||||
| MPTP | ||||||||
| %Respond | 16.1/15.3b | 16.1/10.6b | ||||||
| Latency (ms) | 250/175b | 225/175b | ||||||
| Duration (ms) | 100/75b | 100/100b | ||||||
| GP → GPe | ||||||||
| Normal | ||||||||
| %Respond | 19.4 | 32.3 | 26.9 | 31.2 | 33.3 | 33.3 | 24.7 | 29.0 |
| Latency (ms) | 60 | 60 | 60 | 60 | 60 | 60 | 60 | 70 |
| Duration (ms) | 110 | 90 | 70 | 120 | 10 | 60 | >100 | >100 |
| MPTP | ||||||||
| %Respond | 24.3 | 22.4 | 38.1 | 25.0 | 44.7 | 27.0 | 38.9 | 27.0 |
| Latency (ms) | 60 | 90 | 60 | 80 | 60 | 90 | 60 | 60 |
| Duration (ms) | 40 | 140 | 90 | 140 | 90 | 110 | >100 | >100 |
| GP → GPi | ||||||||
| Normal | ||||||||
| %Respond | 60 | 13.3 | 66.7 | 16.7 | 76.7 | 26.7 | 73.3 | 3.3 |
| Latency (ms) | 70 | 250 | 60 | 230 | 60 | 190 | 60 | >100 |
| Duration (ms) | 70 | 30 | 80 | 140 | 60 | >200 | >100 | >100 |
| MPTP | ||||||||
| %Respond | 64.4 | 26.7 | 66.7 | 31.1 | 57.8 | 24.4 | 40 | 22.2 |
| Latency (ms) | 60 | 150 | 60 | 120 | 60 | 180 | 70 | 60 |
| Duration (ms) | 50 | 360 | 50 | 230 | 50 | >200 | >100 | >100 |
| CTX → GPe | ||||||||
| CTX → GPi | ||||||||
| Normal | ||||||||
| MPTP | ||||||||
| %Respond | 15.9 | 13.6 | ||||||
| Latency (ms) | 120 | 120 | ||||||
| Duration (ms) | 90 | 140 | ||||||
A summary of the main effects of microstimulation, including percentages of neurons responding by decrease (Dec) and by increase (Inc) in the firing rate, latencies (from beginning of the stimulation burst until the peak response), and durations of the responses. The values are given for each neural population and frequency stimulation, in each of the states (normal and MPTP). Details are given only for structures and stimulation frequencies with a significant number of responses, and populations that had no significant response in any of the frequencies are in bold.
aFirst and second values (separated by /) refer to the first excitation phase and to the rebound excitation phase, respectively.
bFirst and second values refer to monkeys T and W, respectively. In all other cases, no significant differences were found between monkeys T and W, and their results are grouped.