Figure 11.

Characterization of WT and PK-KO glia-conditioned mediums. A, GSH concentration in GCM from WT or PK-KO. B, Dose-dependent GSH effects on WT midbrain neuronal cultures. C, [³H]DA uptake in WT midbrain neurons treated with PK-KO-GCM and GSH. Values are the mean ± SEM of two independent cultures with six replicates each. Statistical analysis was performed by one-way ANOVA, followed by Newman–Keuls multiple comparison test. ⁺p < 0.05; ⁺⁺p < 0.01; ⁺⁺⁺p < 0.001, PK-KO-GCM versus WT glia-conditioned medium. *p < 0.05; **p < 0.01; ***p < 0.001, GCM versus EF12 incubated cultures. ^Δp < 0.05 PK-KO-GCM plus GSH versus PK-KO-GCM.