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. 2008 Jan 16;28(3):622–632. doi: 10.1523/JNEUROSCI.2986-07.2008

Figure 8.

Figure 8.

Molecular mechanisms of cellular repulsion are dysregulated in Ctip2−/− striatum. A, B, Coronal sections of wild-type (A) and Ctip2−/− (B) brain at E15.5, showing comparable distribution of Secretagogin-positive cells at early stages of striatal development. C, D, Sagittal/oblique sections of wild-type (C) and Ctip2−/− (D) forebrain at P0, showing the distribution of Secretagogin-positive cells. C, Wild-type brain shows typical distribution of secretagogin cells ventral to the striatum and in the olfactory bulb (arrows). D, In contrast, large clusters of Secretagogin cells infiltrate the Ctip2−/− striatum (arrowhead). E–J, In situ hybridizations of coronal sections through wild-type (E, G, I) and Ctip2−/− (F, H, J) striatum at P0, Neuropilin 1 is absent from the wild-type striatum (E), but is expressed within cellular aggregates in the mutant striatum (F, arrows). Developing wild-type and Ctip2−/− striatum exhibits equivalent levels of Semaphorin 3A (G, H) and Semaphorin 3F (I, J) expression. str, Striatum; MGE, medial ganglionic eminence; ob, olfactory bulb. Scale bars: A, B, 50 μm; C–J, 100 μm.