Figure 1.

Constructs of Tau derived from Tau repeat domain. The top bar diagram represents the longest isoform of the human tau40 (441 residues). The bottom diagram shows the four-repeat construct Tau_RD derived from htau40. One of the constructs used here contains the FTDP17 mutation ΔK280 to accelerate aggregation by promoting β-structure (proaggregation mutant). The second mutant has additionally two proline mutations (I277P and I308P in the hexapeptide motifs) to inhibit the aggregation by disrupting β-structure (antiaggregation mutant).