Figure 4.
NFTs in proaggregation but not in antiaggregation mice. A, Gallyas-positive neurons in the entorhinal cortex of proaggregation mutant mice at 3 months after TauRD/ΔK280 gene expression. B, Absence of Gallyas-positive neurons in the entorhinal cortex of antiaggregation mice at 22 months after TauRD/ΔK280/2P gene expression. C, Thioflavin S staining of the entorhinal cortex confirms the presence of NFTs in proaggregation mice at 3 months after TauRD/ΔK280 gene expression and absence of NFTs in the antiaggregation mutant (D) at 3 months after TauRD/ΔK280/2P gene expression. Scale bars: A–D, 20 μm. Ent, Entorhinal cortex.