Figure 4.
Response of nodose neurons to menthol and icilin. A, Simultaneous recording of [Ca2+]i (top trace) and bath temperature (bottom trace) in four nodose neurons showing the different responses to 100 μm menthol. The majority of CS neurons were potentiated by menthol (CS-MS, green trace), the rest were insensitive or slightly inhibited by menthol (CS-MI, black trace). In contrast, the majority of CI neurons were insensitive to menthol (CI-MI, red trace) and only a small fraction were sensitized by menthol (CI-MS, blue trace). B, Distribution of responses to menthol among CS and CI neurons. C, Response of a CS nodose neuron to 10 and 50 μm icilin. D, Average effects of 10 and 50 μm icilin on thermal threshold. *p < 0.05; **p < 0.01.