Table 2.
Ipsilateral retinal projections
| WT (n = 5) | ephrin-A2−/− (n = 6) | ephrin-A2/A5−/− (n = 4) | |
|---|---|---|---|
| Retina | |||
| Area occupied by ipsilateral RGCs (mm2) | 3.16 ± 0.07 | 3.85 ± 0.11* | 4.18 ± 0.25* |
| RCG density (per mm2) | 244 ± 17 | 262 ± 13 | 243 ± 21 |
| Number ipsilateral RCGs | 734 ± 44 | 994 ± 64* | 1005 ± 48* |
| Percentage of ipsilateral RGCs in total RGC population | 1.39 ± 0.09 | 1.71 ± 0.11 | 1.93 ± 0.12* |
| Superior colliculus | |||
| Caudal limit of dense projection (% of SC length) | 46.42 ± 1.49 | 51.54 ± 0.69 | 55.61 ± 1.07* |
| Volume of ipsilateral terminals (×10−6 mm3) | 9.83 ± 0.11 | 7.76 ± 0.14 | 21.78 ± 0.16* |
| Density of ipsilateral terminals (% pixels) | |||
| Dense patches in deep sgs | 29.05 ± 11.5 | 57.53 ± 5.88* | 53.27 ± 7.81* |
| Diffuse terminals throughout sgs | |||
| Rostral | 0.27 ± 0.07 | 3.41 ± 1.76* | 3.27 ± 1.70* |
| Medial | 0.43 ± 0.25 | 2.41 ± 0.49* | 2.01 ± 0.34* |
| Caudal | 0.00 ± 0.00 | 0.00 ± 0.00 | 13.83 ± 2.91* |
Values are means ± SEM for each genotype. The density of ipsilateral terminals is shown for the dense patches of terminal clusters (appropriate distribution) as well as for the diffuse terminals observed in ephrin-A−/− mice (inappropriate distribution). The density of diffuse terminals is shown separately for the rostral, medial, and caudal SC. Values in rostral and medial SC in WT are not significantly above background.
*Values are significantly different compared with WT.