Table 1.
Kcnc-null allele dependence of electrophysiological and behavioral parameters
| Genotype (Kv3.1; Kv3.3) |
||||||
|---|---|---|---|---|---|---|
| +/+; +/+ | +/+; −/− | +/+; −/− rescue | +/+; +/− | +/−; −/− | +/−; −/− rescue | |
| Input resistance (MΩ) | 23.3 ± 0.83 (29) | 24.2 ± 0.75 (28) | 23.6 ± 1.23 (17) | ND | ND | ND |
| Simple spike width (ms) | 0.15 ± 0.004 (31) | 0.26 ± 0.005*** (33) | 0.14 ± 0.006 (21) | ND | ND | ND |
| Interspike interval (ms) | 9.56 ± 1.02 (14) | 14.2 ± 1.30* (10) | 7.31 ± 0.72 (7) | ND | ND | ND |
| Slope (Hz/200 pA) | 29.3 ± 3.19 (9) | 11.8 ± 2.55** (7) | 25.8 ± 3.42 (6) | ND | ND | ND |
| Spikelets in complex spikes | 2.61 ± 0.29 (15) | 1.17 ± 0.17*** (10) | 2.30 ± 0.25 (7) | ND | ND | ND |
| Instantaneous frequency (Hz) | 625 ± 39 (15) | 214 ± 9*** (10) | 694 ± 85 (7) | ND | ND | ND |
| Pause after complex spike (ms) | 12.4 ± 1.29 (14) | 23.4 ± 3.65** (10) | 13.0 ± 1.68 (7) | ND | ND | ND |
| Lateral deviation index (mm) | 0.52 ± 0.03 (23) | 0.71 ± 0.04*** (33) | 0.59 ± 0.03 (27) | 0.55 ± 0.02 (29) | 0.84 ± 0.03*** (12) | 0.72 ± 0.05** (7) |
| Slips on 1 cm beam, day 1 | 1.79 ± 0.26 (23) | 6.18 ± 0.85** (32) | 4.12 ± 0.51# (27) | 4.97 ± 0.93 (29) | 11.1 ± 1.45** (12) | 9.14 ± 2.37 (7) |
| Slips on 1 cm beam, day 5 | 0.38 ± 0.07 (23) | 1.27 ± 0.26** (32) | 0.48 ± 0.08 (27) | 0.31 ± 0.06 (29) | 1.30 ± 0.34*** (12) | 0.66 ± 0.28 (7) |
For several electrophysiological and behavioral measures, the Kcnc-null allele dependence is shown. The numbers of independent data points are listed in parentheses (cells for electrophysiological measures and mice for behavior). ND, Not determined.
Significant differences from wild type are highlighted in bold (#p = 0.051; *p < 0.05; **p < 0.01; ***p < 0.001).