Figure 5.
Noncompetitive NMDA antagonist does not alter CVNMDA. A, Comparison of EPSC variance mediated by AMPARs and NMDARs. EPSC amplitudes are plotted against stimulus number with holding potential and application of DNQX and DCK indicated schematically. Access resistance magnitude is plotted against stimulus number. Top black traces represent average traces in the different conditions, and the gray traces are SDs. For this neuron, CVAMPA was 0.32, and CVNMDA was 0.25. Application of DCK decreased NMDA current but did not increase CVNMDA (0.23). B, Bar histogram summarizing DCK effect on CVNMDA relative to CVAMPA. In group 1 neurons (CVNMDA < CVAMPA), application of DCK did not alter CVNMDA (DCK). C, In group 2 neurons (CVNMDA ≥ CVAMPA), application of DCK or d-AA did not alter CVNMDA.