Table 3.

Regions showing high betweenness in cortical networks of AD patients

Regions	Class	Normalized betweenness,bi	Degree,ki
Right lateral fronto-orbital gyrus	Paralimbic	3.39	13
Right cingulate region	Paralimbic	3.00	18
Left lingual gyrus	Association	2.87	13
Left lateral occipitotemporal gyrus	Association	2.33	8
Right lingual gyrus	Association	2.31	10
Left middle temporal gyrus	Association	2.25	5
Right superior occipital gyrus	Association	2.06	9
Left medial fronto-orbital gyrus	Paralimbic	1.94	5
Right medial fronto-orbital gyrus	Paralimbic	1.91	12
Left superior temporal gyrus	Association	1.81	7
Left uncus	Paralimbic	1.81	7
Left supramarginal gyrus	Association	1.57	6
Left inferior frontal gyrus	Association	1.55	9
Right middle frontal gyrus	Association	1.52	12

The hub regions (b_i> 1.5) in the structural cortical network of the AD group were listed in a descending order of their normalized betweenness, b_i. The regions were classified as primary, association, and paralimibic as described by Mesulam (1998). k_i denotes the degree of region i. For statistical properties of all regions included in the cortical network, see supplemental Table 3 (available at www.jneurosci.org as supplemental material).