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. 2008 Apr 9;28(15):3877–3886. doi: 10.1523/JNEUROSCI.0675-08.2008

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Copyright © 2008 Society for Neuroscience 0270-6474/08/283877-10$15.00/0

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Figure 1. — A, Prnp^0/0 neurons possess a reduced slow afterhyperpolarization. Ai, A train of 50 action potentials at 20 Hz, evoked both a medium and slow AHP in Prnp ^+/+ (black traces) and Prnp^0/0 (gray traces) neurons. The medium AHP was defined by its rapid kinetics and was observed immediately after cessation of action potential firing. The slow AHP was defined by its slower kinetics and was smaller in Prnp^0/0 neurons at all frequencies tested (Aii). B, A 300 ms depolarization from −65 to +5 mV activated both a medium AHP current (I _mAHP), which displayed faster kinetics and was observed immediately after cessation of the depolarization and slow AHP current (I _sAHP) which displayed slower kinetics. Similar to the slow afterhyperpolarization, the I _sAHP was smaller in Prnp^0/0 neurons. ***p < 0.001.