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. 2008 Apr 9;28(15):3877–3886. doi: 10.1523/JNEUROSCI.0675-08.2008

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Copyright © 2008 Society for Neuroscience 0270-6474/08/283877-10$15.00/0

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Figure 3. — Ca²⁺ signaling is perturbed in Prnp^0/0 neurons. A, Prnp^0/0 neurons (gray traces) produce weaker Ca²⁺ transients, in both somatic (left) and dendritic regions (right), in response to 50 action potentials evoked at 20 Hz. B, Peak Ca²⁺ changes were significantly reduced across the frequency range (p < 0.001, ANOVA; •, Prnp ^+/+; ○, Prnp^0/0) for both somatic (left) and dendritic (right) regions. C, The resting Ca²⁺ level was significantly reduced in Prnp^0/0 neurons in both the somatic (left) and proximal dendritic (right) regions. Somatic and dendritic regions were not significantly different. *p < 0.05; **p < 0.01; ***p < 0.005.